dc.contributor.author | Korovljev, Darinka | |
dc.contributor.author | Javorac, Dejan | |
dc.contributor.author | Todorovic, Nikola | |
dc.contributor.author | Ranisavljev, Marijana | |
dc.contributor.author | Engeset, Dagrun | |
dc.contributor.author | Stea, Tonje Holte | |
dc.contributor.author | Ostojic, Jelena | |
dc.contributor.author | Bijelic, Katarina | |
dc.contributor.author | Conic, Branislava Srdjenovic | |
dc.contributor.author | Kladar, Nebojsa | |
dc.contributor.author | Ratgeber, Laszlo | |
dc.contributor.author | Trunic, Nenad | |
dc.contributor.author | Rajkovic, Sava | |
dc.contributor.author | Stajer, Valdemar | |
dc.contributor.author | Ostojic, Sergej | |
dc.date.accessioned | 2024-03-12T12:55:24Z | |
dc.date.available | 2024-03-12T12:55:24Z | |
dc.date.created | 2023-10-22T13:28:36Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Korovljev, D., Javorac, D., Todorovic, N., Ranisavljev, M., Engeset, D., Stea, T. H., Ostojic, J., Bijelic, K., Conic, B. S., Kladar, N., Ratgeber, L., Trunic, N., Rajkovic, S., Stajer, V. & Ostojic, S. (2023). The Effects of 12-Week Hydrogen-Rich Water Intake on Body Composition, Short-Chain Fatty Acids Turnover, and Brain Metabolism in Overweight Adults: A Randomized Controlled Trial. Current Topics in Nutraceuticals Research, 21(3), 235-241. | en_US |
dc.identifier.issn | 2641-452X | |
dc.identifier.uri | https://hdl.handle.net/11250/3121976 | |
dc.description.abstract | The aim of this randomized controlled trial was to analyze the effects of medium-term supplementation with hydrogen-rich water on brain metabolism, appetite-regulating hormones, body composition, and safety biomarkers in overweight adults. Twenty (n = 20, 10 females) apparently healthy adults with a body mass index >24.9 kg/m2 were assigned to receive 0.5 L per day of hydrogen-rich water (7.5 mg of hydrogen) or hydrogen-free water (tap water) for 12 weeks. Two-way analysis of variance with repeated measures revealed a significant difference between the two interventions in several body composition indices (P ≤ 0.05), with hydrogen-rich water superior to placebo to reduce waist circumference and mid-upper arm circumference by 1.31 cm (95% confidence interval, from –0.23 to 2.85) and 0.65 cm (95% confidence interval, from –0.10 to 1.40), respectively. Hydrogen-rich water outcompeted placebo to raise serum ghrelin levels, as the mean difference from the placebo group was 17.28 pmol/L (95% confidence interval, from 1.81 to 32.75) (P = 0.02). A non-significant strong positive trend (P = 0.10) was reported toward hydrogen-rich water being superior to placebo in augmenting total serum short-chain fatty acid levels, with a mean difference from the control group of 195.6 μmol/L (95% confidence interval, from –64.55 to 275.85). The mean fecal calprotectin levels were significantly reduced after hydrogen-rich water intervention for 19.7 μg/mg (95% confidence interval, from 0.31 to 39.09) (P = 0.03). Our findings advance hydrogen-rich water as a promising metabolic intervention in overweight adults, but further validation via multicentric longitudinal randomized controlled trials in metabolic and nutritional disorders is required. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | New Century Health Publishers LLC | en_US |
dc.title | The Effects of 12-Week Hydrogen-Rich Water Intake on Body Composition, Short-Chain Fatty Acids Turnover, and Brain Metabolism in Overweight Adults: A Randomized Controlled Trial | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2023 by New Century Health Publishers, LLC | en_US |
dc.subject.nsi | VDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811 | en_US |
dc.source.pagenumber | 235-241 | en_US |
dc.source.volume | 21 | en_US |
dc.source.journal | Current Topics in Nutraceuticals Research | en_US |
dc.source.issue | 3 | en_US |
dc.identifier.doi | https://doi.org/10.37290/ctnr2641-452X.21:235-241 | |
dc.identifier.cristin | 2187341 | |
dc.description.localcode | Paid open access | en_US |
dc.source.articlenumber | 5 | en_US |
cristin.qualitycode | 1 | |