dc.contributor.author | Ostojic, Sergej | |
dc.date.accessioned | 2022-03-16T12:57:28Z | |
dc.date.available | 2022-03-16T12:57:28Z | |
dc.date.created | 2021-12-23T09:40:36Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Ostojic, S. (2021). Safety of dietary guanidinoacetic acid: a villain of a good guy?. Nutrients, 14 (1). Artikkel 75. | en_US |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | https://hdl.handle.net/11250/2985566 | |
dc.description.abstract | Guanidinoacetic acid (GAA) is a natural amino acid derivative that is well-recognized for its central role in the biosynthesis of creatine, an essential compound involved in cellular energy me-tabolism. GAA (also known as glycocyamine or betacyamine) has been investigated as an ener-gy-boosting dietary supplement in humans for more than 70 years. GAA is suggested to effective-ly increase low levels of tissue creatine and improve clinical features of cardiometabolic and neurological diseases, with GAA often outcompetes traditional bioenergetics agents in maintain-ing ATP status druing stress. This perhaps happens due to a favorable delivery of GAA through specific membrane transporters (such as SLC6A6 and SLC6A13), previously dismissed as un-targetable carriers by other therapeutics, including creatine. The promising effects of dietary GAA might be countered by side-effects and possible toxicity. Animal studies reported neurotoxic and pro-oxidant effects of GAA accumulation, with exogenous GAA also appears to increase methylation demand and circulating homocysteine, implying a possible metabolic burden of GAA intervention. This mini-review summarizes GAA toxicity evidence in human nutrition, and outlines functional GAA safety through benefit-risk assessment and multi-criteria decision anal-ysis | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Safety of dietary guanidinoacetic acid: a villain of a good guy? | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2021 The Author(s) | en_US |
dc.subject.nsi | VDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811 | en_US |
dc.source.volume | 14 | en_US |
dc.source.journal | Nutrients | en_US |
dc.source.issue | 1 | en_US |
dc.identifier.doi | https://doi.org/10.3390/nu14010075 | |
dc.identifier.cristin | 1971652 | |
dc.relation.project | Universitetet i Agder: 689019 | en_US |
dc.source.articlenumber | 75 | en_US |
cristin.qualitycode | 1 | |