Untreated osteoporosis and higher FRAX as risk factors for tooth loss: a 5‑year prospective study
Penoni, Daniela Cia; Torres, Sandra Regina; Oliveira, Matheus L; Farias, Maria Lucia Fleiuss; Vettore, Mario Vianna; Leão, Anna Thereza Thomé Leão
Peer reviewed, Journal article
Accepted version
Åpne
Permanent lenke
https://hdl.handle.net/11250/3086618Utgivelsesdato
2023Metadata
Vis full innførselSamlinger
Originalversjon
Penoni, Daniela Cia Torres, Sandra Regina Oliveira, Matheus L Farias, Maria Lucia Fleiuss Vettore, Mario Vianna Leão, Anna Thereza Thomé Leão (2023). Untreated osteoporosis and higher FRAX as risk factors for tooth loss: a 5-year prospective study. Journal of Bone and Mineral Metabolism, 1-11. https://doi.org/10.1007/s00774-023-01451-wSammendrag
Introduction Studies have shown that an impaired bone condition, represented by osteoporosis and increased fracture risk, may potentially aggravate periodontal disease and, consequently, the risk of tooth loss. This 5-year prospective study aimed to investigate whether systemic bone condition represents risk factor for tooth loss due to periodontal disease amongst elderly women. Material and methods Seventy-four participants, aged≥65 years, who attended the 5-years recall for periodontal evaluation were involved. Baseline exposures were osteoporosis and fracture risk probabilities (FRAX). Women were grouped according to bone mineral density (BMD) and years of bone treatment for osteoporosis. The primary outcome at a 5-year follow-up was the number of tooth loss due to periodontal disease. Periodontitis staging and grading, and causes of tooth loss were recorded. Results The multivariate Poisson regression models showed that women with untreated/shortly treated osteoporosis were 4 times more likely to present higher number of tooth loss due to periodontal disease than those with normal BMD or treated for≥3 years (risk ratio (RR)=4.00, 95% CI 1.40– 11.27). Higher FRAX was also linked to tooth loss (RR=1.25, 95% CI 1.02–1.53). Receiver-operating characteristic (ROC) curve suggested that women with history of≥1 tooth losses have higher chances of worse major FRAX (sensitivity=72.2%; specifcity=72.2%). Conclusion In this 5-year study, higher FRAX and untreated osteoporosis were risk factors for tooth loss. Women with normal BMD or treated for osteoporosis for≥3 years did not show increased risk. Management of skeletal conditions should be emphasized with periodontal care for the prevention of tooth loss in elderly women.