A roadmap for understanding the evolutionary significance of structural genomic variation
Peer reviewed, Journal article
Accepted version
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https://hdl.handle.net/11250/3048867Utgivelsesdato
2020Metadata
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Originalversjon
Mérot, C., Oomen, R. A., Tigano, A. & Wellenreuther, M. (2020). A Roadmap for Understanding the Evolutionary Significance of Structural Genomic Variation. Trends in Ecology & Evolution, 35(7), 561-572. https://doi.org/10.1016/j.tree.2020.03.002Sammendrag
Structural genomic variants (SVs) take diverse forms and are ubiquitous drivers of ecological and evolutionary processes. Most studies of SVs focus on the adaptive significance of gene duplications and large inversions. Future studies should catalog SVs of all types and sizes and systematically test their evolutionary implications. We propose a roadmap and definitions for the study of SVs in ecological and evolutionary genomics. Best practices for SV detection are needed to facilitate comparisons across studies. Integrating population genomic, theoretical, and experimental approaches to SVs will more comprehensively characterize genomic variation, uncover the adaptive and neutral processes shaping the evolutionary trajectory of SVs, and identify the mechanisms by which SVs impact adaptation and speciation.
Beskrivelse
Author's accepted manuscript