Effekten av Citrulline Malate på blodstrøm hos unge friske menn
Master thesis
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https://hdl.handle.net/11250/3042497Utgivelsesdato
2022Metadata
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Sammendrag
The use of ergogenic compounds has gained increasing popularity among athletes who wish toimprove athletic performance and recover faster from their workouts. Among these products isCitrulline Malate (CitMal); a precursor to nitric oxide (NO) that promises to enhance bloodflow to exercising muscles. To evaluate the purported effect on blood flow we assessed bloodflow in the arm of 12 healthy, recreationally active men (23 ± 3 years) pre and post intake ofplacebo, 6 and 12 grams CitMal, with measurements done 1 and 2 hours post intake. Theexperiment was conducted as a randomized, double-blind and placebo-controlled crossoverstudy with ≥ 7-day washout-period between each of the three sessions. Blood flow wasmeasured directly with ultrasound doppler in the reactive hyperemic state (FLOW) andindirectly by assessing the dilator capacity of the brachial artery (a. brachialis) in the activehyperemic state (FMD). Repeated measures ANOVA revealed no statistically significantchange in FLOW or FMD 1 and 2 hours post intake of placebo, 6 and 12 grams CitMalcompared to baseline values. The measurement data were also not statistically significantlydifferent between the groups at any of the measurement times, neither for FLOW nor FMD.Out of the 12 participants, 8 of them underwent blood assessments after all blood flowmeasurements were completed to assess the dose-response relationship between CitMal (6 and12 grams, time window: 0-120 min) and blood markers involved in the production of NO.Independent t-test revealed statistically significant higher serum levels of arginine and higherratio-values between arginine and its methylated derivatives symmetric dimethylarginine(SDMA) and asymmetric dimethylarginine (ADMA) at all measurement times afterconsumption of 6 and 12 grams of CitMal compared to baseline values. Taken together, thesedata provide evidence that CitMal does not increase blood flow to musculature in the active-nor reactive hyperemic state in young healthy males with normal blood levels of arginine.
Keywords: Citrulline Malate, nitric oxide, blood flow, arginine, symmetric- and asymmetricdimethylarginine.