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dc.contributor.authorDemmelmaier, Ingrid
dc.contributor.authorBrooke, Hannah L.
dc.contributor.authorHenriksson, Anna
dc.contributor.authorMazzoni, Anne-Sophie
dc.contributor.authorBjørke, Ann Christin Helgesen
dc.contributor.authorIgelström, Helena
dc.contributor.authorAx, Anna-Karin
dc.contributor.authorSjövall, Katarina
dc.contributor.authorHellbom, Maria
dc.contributor.authorPingel, Ronnie
dc.contributor.authorLindman, Henrik
dc.contributor.authorJohansson, Silvia
dc.contributor.authorVelikova, Galina
dc.contributor.authorRaastad, Truls
dc.contributor.authorBuffart, Laurien M.
dc.contributor.authorÅsenlöf, Pernilla
dc.contributor.authorAaronson, Neil K.
dc.contributor.authorGlimelius, Bengt
dc.contributor.authorNygren, Peter
dc.contributor.authorJohansson, Birgitta
dc.contributor.authorBörjeson, Sussanne
dc.contributor.authorBerntsen, Sveinung
dc.contributor.authorNordin, Karin
dc.identifier.citationDemmelmaier, I., Brooke, H. L., Henriksson, A., Mazzoni, A.-S., Bjørke, A. C. H., Igelström, H., Ax, A.-K., Sjövall, K., Hellbom, M., Pingel, R., Lindman, H., Johansson, S., Velikova, G., Raastad, T., Buffart, L. M., Åsenlöf, P., Aaronson, N. K., Glimelius, B., Nygren, P., Johansson, B., Börjeson, S., Berntsen, S. & Nordin, K. (2021). Does exercise intensity matter for fatigue during (neo-)adjuvant cancer treatment? The Phys-Can randomized clinical trial. Scandinavian Journal of Medicine & Science in Sports, 31 (5), 1144-1159.en_US
dc.description.abstractExercise during cancer treatment improves cancer-related fatigue (CRF), but the importance of exercise intensity for CRF is unclear. We compared the effects of high- vs low-to-moderate-intensity exercise with or without additional behavior change support (BCS) on CRF in patients undergoing (neo-)adjuvant cancer treatment. This was a multicenter, 2x2 factorial design randomized controlled trial (Clinical Trials NCT02473003) in Sweden. Participants recently diagnosed with breast (n = 457), prostate (n = 97) or colorectal (n = 23) cancer undergoing (neo-)adjuvant treatment were randomized to high intensity (n = 144), low-to-moderate intensity (n = 144), high intensity with BCS (n = 144) or low-to-moderate intensity with BCS (n = 145). The 6-month exercise intervention included supervised resistance training and home-based endurance training. CRF was assessed by Multidimensional Fatigue Inventory (MFI, five subscales score range 4-20), and Functional Assessment of Chronic Illness Therapy-Fatigue scale (FACIT-F, score range 0-52). Multiple linear regression for main factorial effects was performed according to intention-to-treat, with post-intervention CRF as primary endpoint. Overall, 577 participants (mean age 58.7 years) were randomized. Participants randomized to high- vs low-to-moderate-intensity exercise had lower physical fatigue (MFI Physical Fatigue subscale; mean difference −1.05 [95% CI: −1.85, −0.25]), but the difference was not clinically important (ie <2). We found no differences in other CRF dimensions and no effect of additional BCS. There were few minor adverse events. For CRF, patients undergoing (neo-)adjuvant treatment for breast, prostate or colorectal cancer can safely exercise at high- or low-to-moderate intensity, according to their own preferences. Additional BCS does not provide extra benefit for CRF in supervised, well-controlled exercise interventions.en_US
dc.publisherJohn Wiley & Sonsen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleDoes exercise intensity matter for fatigue during (neo-)adjuvant cancer treatment? The Phys-Can randomized clinical trialen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2021 The Author(s)en_US
dc.subject.nsiVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.subject.nsiVDP::Medisinske Fag: 700::Idrettsmedisinske fag: 850en_US
dc.source.journalScandinavian Journal of Medicine & Science in Sportsen_US
dc.relation.projectThe Swedish Cancer Society: 150841en_US
dc.relation.projectThe Swedish Research Council: KDB/9514en_US
dc.relation.projectThe Nordic Cancer Union: 2015en_US
dc.relation.projectThe Oncology Department Foundations Research Fund in Uppsala: 2016, 2017en_US
dc.description.localcodePaid Open Accessen_US
dc.description.localcodeUNIT agreementen_US

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal