Effects of 6-Month Supplementation with Multi-Component Herbal Supplement PhytodynamicTM on Mitochondrial Function, Telomere Length, and Chronic Inflammation in Adults Aged 65 Years and Older: A Pilot Trial
Todorovic, Nikola; Korovljev, Darinka; Stajer, Valdemar; Maksimovic, Nebojsa; Ratgeber, Laszlo; Betlehem, Jozsef; Acs, Pongrac; Ostojic, Sergej
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2022Metadata
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Todorovic, N., Korovljev, D., Stajer, V., Maksimovic, N., Ratgeber, L., Betlehem, J., Acs, P. & Ostojic, S. (2022). Effects of 6-Month Supplementation with Multi-Component Herbal Supplement PhytodynamicTM on Mitochondrial Function, Telomere Length, and Chronic Inflammation in Adults Aged 65 Years and Older: A Pilot Trial. Current Topics in Nutraceuticals Research, 20(3), 594-597. https://doi.org/10.37290/ctnr2641-452X.20:594-597Abstract
Herbal supplements are often used by elderly populations in aim to manage age-related traits; yet, most have shown limited benefits, keeping a quest for safe and effective longevity-promoting mixtures open. The main aim of the present study was to evaluate the effects of 6-month supplementation with multi-component herbal mixture P-DNA for telomere length, biomarkers of mitochondrial function and chronic inflammation, and self-reported adverse events in men and women aged 65 years and older. Fourteen older adults (74.6 ± 6.3 years, height 164.1 ± 13.0 cm, weight 69.9 ± 13.4 kg; 11 women) signed an informed consent to voluntarily participate in this randomized controlled parallel-group pilot trial. All participants were allocated in a double-blind design to receive either P-DNA or placebo (inulin) during a 6-month intervention period, with the outcomes assessed at baseline and 6-month follow-up were biomarkers of mitochondrial function (fibroblast growth factor 21, growth-differentiation factor 15), inflammation (high-sensitive C-reactive protein, interleukin-6, and amyloid A), and telomere length. Two-way analysis of variance with repeated measures was used to establish if any significant differences existed between patients’ responses over time of intervention; for data with nonhomogenous variances the Kruskal– Wallis test was employed for the between group comparisons and Freidman’s test for the within group comparisons. Growth-differentiation factor 15 significantly dropped after PhytoDyNAmicTM intervention as compared to the baseline levels (P = 0.02), while serum interleukin-6 significantly increased from baseline levels in both groups at 6-month follow-up (P < 0.05). No participant reported major side effects of any intervention. PhytoDyNAmicTM appears to favorably affect mitochondrial function in adults aged 65 years and older; additional studies are needed to corroborate these promising findings.